The best treatment approach begins in the office with a program that attends to all the significant issues in the epidermis and dermis and continues with an at-home regimen to keep up and expand these results. Chemical peels have always been the least expensive treatment modality and are classified as superficial, medium, or profound. They are used primarily to discuss mild pigmentary alterations such as lentigines or age spots or with laser devices whose target chromophore is melanin. In general, an IPL device is usually the first choice because it will normalize the pigment of the entire dorsal surface of the hand. Treatment with fractionated devices is a more aggressive approach to rejuvenating the epidermis—one that could more significantly improve the skin's overall texture. Newly prominent age- and UV-related vessels, tendons, and bones can be addressed through re-volumization. By plumping the hands, I can achieve tissue laxity and a reduction of vascular and bony prominences. Several different filters, including autologous fat injections, can be safely used in the hands. Vein removal is often found to be unnecessary after volume restoration. However, if bulging or prominent veins stay a cosmetic problem, they can be treated with sclerotherapy or laser removal. A multi-modal approach to hand rejuvenation obtains the best results.