Vitiligo causes the skin to lose its natural color in hair, eyes, and mouth. Segmental vitiligo is a subtype of vitiligo with a specific unilateral distribution. What causes this color loss is still a mystery. We do know that vitiligo is not contagious. It is not life-threatening. The treatments can help stop disease progression, induce re-pigmentation, and decrease relapses risk. Cosmetics, sunscreens, topical corticosteroids, topical and oral PUVA therapy, and narrow-band UVB radiation are some medical treatment modalities used for patients with vitiligo. Different surgical techniques have been devised over the years, including tissue grafts—best results are obtained in segmental subtype vitiligo. Combining two or more treatments often gives the best results. Each treatment method has advantages and disadvantages, and not all procedures are ideal for every patient. It is not possible to predict how a patient will respond to treatment. It is crucial to remember that no one treatment works for everyone. Results can vary from one part of the body to another.