Acne is one of the most common diseases with a point prevalence of up to 100% among adolescents and often persists into adulthood, with detrimental effects on self-esteem. The conception of acne has been refined towards ‘chronic disease.’ Therefore, the strategy of acne treatment is not only a critical intervention but also maintenance. Acne medications are very efficient, but only when patients use them correctly. Oral isotretinoin is the most effective acne treatment developed to date. Earlier procedures, such as intralesional steroids, chemical peels, and microdermabrasion have been replaced by newer methods. Newer methods include radiofrequency, light or laser, and photodynamic therapy that represent treatment alternatives for systemic medications.